PKN1 modulates TGFß and EGF signaling in HEC-1-A endometrial cancer cell line
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چکیده
منابع مشابه
PKN1 modulates TGFβ and EGF signaling in HEC-1-A endometrial cancer cell line
BACKGROUND The response of cells to TGFβ and EGF is mediated by a network of various intracellular regulators. The signaling crosstalk between different regulators is of key importance for tumorigenesis. The crosstalk may explain the modulation of cellular responses to the same regulator by another signaling molecule. As PKN1 - a serine/threonine kinase implicated in tumorigenesis - was identif...
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Transforming growth factor-β (TGFβ) and epidermal growth factor (EGF) are two potent regulators of tumorigenesis. Signaling cross-talk of TGFβ and EGF employs a number of regulators which define the impact on cell physiology. MST1 has recently been reported as a regulator of tumorigenesis and differentiation. To investigate the role of mammalian sterile-like 1 (MST1) in TGFβ and EGF signaling, ...
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متن کاملUM-EC-1, a new hypodiploid human cell line derived from a poorly differentiated endometrial cancer.
The University of Michigan endometrial carcinoma cell line UM-EC-1 was derived from a poorly differentiated endometrial adenocarcinoma of a 66-yr-old white female. Cell cultures were started using both tumor explants and a cell suspension obtained from collagenase-treated tumor tissue. The collagenase-derived cell suspension gave rise to monolayer cultures which grew rapidly from the outset. Th...
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ژورنال
عنوان ژورنال: OncoTargets and Therapy
سال: 2014
ISSN: 1178-6930
DOI: 10.2147/ott.s65051